Antonio Domingos began his musical studies at the age of 7 in his native city of Pittsburgh, Pennsylvania, USA. At the age of 14, in order to further his musical education, he traveled to Moscow, Russia, where he was admitted to the Moscow Academic Music College, a high-school-level affiliate institution of the Moscow State Conservatory, from which he graduated in 1995, having been known there as 'Antonio Gomes'. In 1996, he entered the Moscow State Conservatory proper, from which he graduated in 2001 with the highest classification, having pursued a degree in piano performance under the tutelage of professor D. Sakharov.

In 1995, he was awarded third prize at the first international Vladimir Horowitz Competition for Young Pianists in Kiev, Ukraine.

In 2002, he settled in Portugal, where he adopted the stage name 'Domingos António' and was active as a concert artist over the course of several years.

In 2010, he performed a concert in Braga, Portugal, dedicated to the bicentennial of the births of Frédéric Chopin, Robert Schumann, and Franz Liszt.

In 2016, having adopted a new stage name, "Antonio Domingos", he created a YouTube channel titled 'extremepianochannel', on which videos of his playing can be seen.

In 2019, he was mentioned on the second episode of season 17 (S17 E2) of Britain’s popular TV show «QI».